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and the enlistment of social support during the quitting process. On medications Both varenicline and a combination of nicotine patches with short-acting nicotine-replacement therapy are considered the most effective and safe first-line treatments for smoking cessation. They add: Nicotine-replacement therapy is usually started on the patients target quit date (the date that the patient commits to abstaining from smoking for at least 24 hours), whereas non-nicotine oral medications are started at least 1 week before